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Proactive Study Start-Up Support: Tailored Strategies for Small and Mid-Sized Sponsors Every clinical supply project comes with its own set of risks, owing to the inherent uniqueness of each study. The complexity of a project can often be traced back to specific characteristics present in the protocol design, study scope, drug properties, and sponsor resources. Addressing these potential challenges demands a holistic and integrated approach during the study start-up phase, along with proactive strategies to avert any issues that may arise. To achieve this, Clinical Supply Management (CSM) takes the helm, serving as the first line of defense in devising a robust execution plan.