The growing need for versatile drug formats is more urgent than ever, addressing patient challenges like swallowing difficulties. Simultaneously, the FDA’s push for pediatric-appropriate drugs places a spotlight on critical factors such as taste, scent, and texture. As the costs for developing and researching these taste masking formulations rise, there’s an increasing demand for manufacturing solutions that are both scalable and cost-efficient.

Physical barrier methods rank among the most effective for taste masking, and Renejix provides practical industrial solutions like microencapsulation and microspheres with high drug loading. These technologies are ideal for creating pediatric-friendly dosage forms, efficiently masking unpleasant tastes.
Image showing a Lady showing a pill

Benefits of taste masking technology

Improve Patient Adherence:

  • By masking the unpleasant flavors of medications, this creates a more pleasant patient experience. This approach is crucial for ensuring that patients, especially those with chronic illnesses, adhere to their medication regimens without being deterred by taste.

Broaden Market Reach:

  • Renejix’s expertise in taste masking allows the company to cater to a diverse patient base, including those who are particularly averse to the taste of medication. This not only improves the user experience but also opens up new market segments for growth and development.

Strengthen Product Stability:

  • Our advanced taste masking techniques often involve protective coatings that do more than just conceal taste; they also protect the active ingredients from degradation due to environmental exposure, thus enhancing the product’s shelf life and efficacy.

Efficacy and Bioavailability:

  • Renejix’s strategic approach to taste masking ensures that the active ingredients are released in the most effective manner, optimizing absorption and maximizing the therapeutic benefits of the medication.

Renejix Provides Versatile Dosage Options:

  • Renejix prides itself on offering a wide array of dosage forms. From chewable tablets to dissolvable strips, the company’s taste masking capabilities enable the creation of user-friendly and innovative medication delivery systems.

Tailored Solutions for Specific Populations:

  • Understanding that different patient groups have unique needs, our scientists customize taste masking solutions to align with the preferences and requirements of each target demographic, ensuring maximum acceptance and satisfaction.


  • With a keen understanding of regulatory landscapes, Renejix ensures that all taste-masked products meet the stringent requirements set forth for pediatric and geriatric formulations, thus facilitating smoother market entry and compliance.

taste Masking Solutions

API Taste Modifiers or Suppressants

  • Sweeteners
  • Flavors
  • Bitter receptor blocker or antagonists
  • Potentiators
  • Effervescents

API Solubility Modifier

  • pH Modifier
  • Gellation or Viscosity
  • Enhancer
  • API Barrier
  • Molecular/Ionic Barrier via complexation [Ion exchange resins or cyclodextrins]
  • Physical barrier via coating or granulation, etc. [polymers or lipids or similar excipients]

API Barrier

  • Molecular/Ionic Barrier via complexation [Ion exchange resins or cyclodextrins]
  • Physical barrier via coating or granulation, etc. [polymers or lipids or similar excipients]

API Modification

Modify solubility or taste using:

  • Salt
  • Polymorph
  • Cocrystal
  • Prodrug

Sensory Modification: We alter the way the medication is perceived by the patient’s senses. 

  • Texture Modifiers: Using agents that change the texture of the medication to make it more palatable.
  • Cooling Agents: Incorporating substances that provide a cooling sensation in the mouth, which can help mask unpleasant tastes.

Flavor Engineering: We go beyond simply adding sweeteners or flavors. 

  • Flavor Pairing: Combining flavors in such a way that they complement each other and enhance the overall taste profile of the medication.
  • Flavor Encapsulation: Encapsulating flavors within a matrix that controls their release, providing a sustained pleasant taste experience throughout the administration of the medication.

Customizable Release Profiles: Developing formulations with customizable release profiles allows for the controlled release of taste-masking agents at the optimal time. This can be achieved through:

  • pH-Responsive Polymers: Designing polymers that dissolve at specific pH levels, releasing taste-masking agents when the medication is in the mouth.
  • Enzyme-Triggered Release: Utilizing formulations that release flavor enhancers in response to enzymes present in saliva.

Taste Masking Technologies

  • Advanced Coating Technologies:
    • Renejix applies aqueous and solvent-based film coatings to enhance tablet integrity, modulate drug release, and improve patient compliance.
    • The company skillfully administers enteric coatings using polymers that dissolve at higher pH, ensuring API protection from stomach acidity and targeted intestinal release.
  • Innovative Complexation Methods:
    • Renejix uses cyclodextrin inclusion complexation, a technique that encapsulates hydrophobic drugs within cyclodextrin molecules to significantly increase their solubility and bioavailability.
    • Our team utilizes polymer-based complexation, leveraging polymers like Eudragit to create matrices that control the release rate of the drug, enhancing therapeutic outcomes.
  • Expert Flavoring Techniques:
    • Our scientists incorporate advanced flavor masking to conceal the unpleasant taste of APIs, using techniques like hot-melt extrusion and spray drying to improve oral medication palatability.
    • They expertly blend natural and artificial flavors, ensuring that the end product is enjoyable for the patient while adhering to stringent regulatory standards.
  • Comprehensive Formulation Services:
    • Renejix formulates sustained-release systems that maintain consistent drug levels in the bloodstream, reducing dosing frequency and side effects.

Renejix advances nanotechnology applications in drug delivery, creating nanoparticles that can traverse biological barriers for targeted therapy and improved efficacy.


Our microencapsulation technology by coacervation is a taste-masking solution with a wide variety of delivery formats.

Uniform coating of a solid particle or liquid droplet with a rigid semi-permeable polymer creates a physical barrier:

  • Effective taste masking
  • Customized release profile
  • Turn liquids into powders
  • Combine incompatible APIs

Final dosage forms:

  • Powder
  • Dry syrup
  • Orally disintegrating tablets
  • oral solids
  • Food-like texture dosage form

Proprietary Taste-Masking Process

The microencapsulation coacervation process can also be used for varying non-isometric particle shapes.

Our taste masking process also offers:

  • Particle dimensions – as small as 150-200 µm
  • Very efficient coating  ~15-20%
  • Adjustable and consistent release profile
  • Rapid production cycle – completed within a single shift
  • Coating volume does not affect processing duration
  • Large scale production capability
  • Accommodates various particle forms


Microparticles at an unprecedented scale:

  • Particle sizes down to 75 μm with Span values as low as 0.40
  • Uses a nitrogen carrier stream
  • Analogous to spray congealing
  • No drying step or coating required
  • Compatible with waxes, lipids, stearates, and gelatins
  • Great for oral small molecules, nutraceuticals,  and heat stable molecules

Produces uniform microspheres and microcapsules with narrow size distribution and precise control over particle structure

Multiparticulates are able to deliver:

  • Uniformity
  • Format Flexibility
  • Dose Flexibility
  • Taste Masking
  • Variable Release Kinetics
  • Single-step Microcapsules

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Here are some frequently asked questions about Taste Masking Technology

What is taste masking, and why is it important in pharmaceutical formulations?

Taste masking refers to the process of concealing the unpleasant taste of active pharmaceutical ingredients (APIs) to make oral medications more palatable. This is crucial for improving patient compliance, especially in pediatric, geriatric, and other patient groups who are particularly sensitive to bitter tastes. Effective taste masking can significantly enhance the acceptability and thus the effectiveness of a medication regimen.

What techniques do you use for taste masking?

Renejix employs a variety of techniques for taste masking, including:

  • Coating: Applying a thin polymer layer around the drug particle or tablet to prevent the immediate release of the drug in the oral cavity.
  • Microencapsulation: Encasing the drug particles in a microscale shell to mask taste until it reaches the desired point of absorption.
  • Complexation: Using substances like cyclodextrins to form complexes with the drug, reducing its availability to taste receptors.
  • Formulation with flavors and sweeteners: Incorporating flavors and sweeteners can help in masking the unpleasant taste of APIs.
  • Use of ion exchange resins: Binding the drug molecules to resins to prevent their release in the mouth.
How do you select the most appropriate taste masking technique for a drug?

Selecting the most appropriate taste masking technique involves evaluating several factors:

  • Chemical properties of the API: Solubility, pH stability, and molecular size can influence the choice of technique.
  • Desired release profile: Immediate release versus controlled or extended release can dictate the suitability of a technique.
  • Target patient population: Considerations such as age, patient sensitivities, and preferences play a crucial role.
  • Regulatory requirements: Compliance with regulatory guidelines for safety and efficacy.
  • Cost-effectiveness: Balancing the cost of the technique with the benefits it offers in terms of patient compliance and product differentiation.
Can taste masking improve drug efficacy?

While taste masking does not directly enhance the pharmacological efficacy of a drug, it can improve drug efficacy indirectly by enhancing patient compliance. When medications are more palatable, patients are more likely to adhere to their prescribed dosing regimen, leading to better treatment outcomes.

Are there any limitations or challenges associated with taste masking?

Limitations and challenges in taste masking include:

  • Maintaining drug efficacy: Ensuring that the taste masking process does not interfere with the drug's bioavailability or therapeutic effect.
  • Regulatory compliance: Meeting the regulatory standards and requirements for safety and efficacy.
  • Cost: Some taste masking techniques can be costly and may impact the final product pricing.
  • Complexity: Developing a suitable taste masking formulation can be complex and requires extensive R&D and testing.
How do you ensure the stability of taste-masked formulations?

Ensuring the stability of taste-masked formulations involves:

  • Stability testing: Conducting rigorous stability tests under various environmental conditions to ensure the formulation maintains its integrity and efficacy over time.
  • Appropriate packaging: Using packaging materials that protect the formulation from moisture, light, and other factors that could compromise stability.
  • Optimized formulation: Carefully selecting excipients and processing conditions that contribute to the stability of the taste-masked product.
What role does patient feedback play in developing taste-masked formulations?

Patient feedback is invaluable in the development of taste-masked formulations. It provides direct insight into the palatability and acceptability of the medication, which can guide formulation adjustments. Patient-centered design, involving taste tests and preference studies, can help optimize the formulation to ensure high levels of patient compliance and satisfaction.

Can taste masking be applied to all types of oral dosage forms?

Taste masking can be applied to most oral dosage forms, including tablets, capsules, liquids, and chewables. However, the suitability and approach to taste masking may vary depending on the dosage form's characteristics and the intended release mechanism (e.g., immediate release versus sustained release).

How do regulatory authorities view taste masking?

Regulatory authorities view taste masking as a critical component of drug formulation that can significantly impact patient compliance. They require that taste-masked products meet all the usual safety and efficacy standards, and that the taste masking process does not adversely affect the drug's pharmacokinetic properties. Detailed documentation of the taste masking development process and its impact on the drug product's performance is required for regulatory submissions.

What advancements are being made in taste masking technologies?

Advancements in taste masking technologies include:

  • Nanotechnology-based approaches: Employing nanoparticles for improved encapsulation and targeted release.
  • Molecular imprinting: Creating polymer networks that selectively bind unpleasant-tasting molecules, preventing them from interacting with taste receptors.
  • Genetic taste profiling: Tailoring formulations based on genetic variations in taste perception to create more universally acceptable medications.
  • Innovative excipients: Developing new excipients that can more effectively mask tastes or enhance the flavoring of oral dosage forms.