Immunocure’s AxDrug Platform embodies a groundbreaking approach to drug discovery, integrating advanced AI and computational chemistry methodologies to propel Hit Identification, Hit to Lead, and Lead Optimization processes. Leveraging deep learning, machine-learning models, and accelerated computation methods, AxDrug navigates the intricate landscape from target validation to lead optimization with precision and efficacy.
Unleash the Power of Molecules: Small Molecule Synthesis at Immunocure
In the intricate dance of drug discovery, small molecule synthesis is the choreographer, masterfully orchestrating the creation of life-altering compounds. At Immunocure, we don’t just synthesize molecules; we sculpt them into potential heroes of tomorrow’s medicine.
Harnessing the Magic of Small Molecules:
Small molecules, the workhorses of modern medicine, possess the remarkable ability to interact with biological targets, influencing disease pathways and unlocking therapeutic potential. From the intricate choreography of enzymes to the nuanced dance of protein interactions, understanding how these molecules move is key to designing them for impact.
Where Science Meets Art:
Small molecule synthesis is more than just chemical equations and lab coats. It’s a tapestry woven with artistry, meticulous planning, and a deep understanding of molecular choreography. Our team of synthetic virtuosos, armed with a symphony of techniques, translates the whispers of discovery chemistry into tangible entities ready to waltz with their biological targets.
Our Symphony of Synthesis Services:
Synthetic Route Design:
We meticulously map the journey from blueprint to molecule, crafting optimal routes for yield, purity, and cost-effectiveness.
Heterocyclic Expertise:
We weave the magic of heterocycles, the building blocks of countless drugs, into diverse and intricate molecular structures.
Asymmetric Mastery:
We command the art of asymmetric synthesis, ensuring stereochemical control for molecules that perform with precision.
Organometallic Alchemy:
We unlock the transformative power of organometallic reagents, forging complex structures with unparalleled efficiency.
Natural Product Analogue Synthesis:
We bridge the gap between nature’s wisdom and pharmaceutical reality, crafting innovative analogues of bioactive natural products and it’s analogs.
Nucleoside & Nucleotide Synthesis:
We orchestrate the synthesis of nucleosides and nucleotides, unlocking their potential in fields like drug discovery and biotechnology.
Carbohydrate Synthesis:
We unravel the complexities of sugars, crafting carbohydrate derivatives for groundbreaking research in glycobiology and medicinal chemistry.
Targeted Protein Degraders:
We design and synthesize bivalent PROTAC molecules, harnessing the power of targeted protein degradation for innovative therapeutic approaches.
Peptide Synthesis:
We compose custom peptides, from simple melodies to complex sonatas, for diverse applications in drug discovery and beyond.
Specialized Areas of Interest:
- Decarboxylative C-C Bond-Forming, Isocyanate Reactions
- Prodrugs (Phosphate/Non-Phosphate)
- Macrocyclic Compounds
- Covalent Inhibitors of cystine, Serine, Lysine and Glutamic acid
- Drug Conjugates for Antibody-Drug Conjugates (ADCs)
- Biotinylated Compounds, BODIPY and Fluorescein-Labeled Compounds
- Derivatives of TBO & MMTP, etc.
- Lipid and Steroid Compounds
- Green Chemistry
Additional Chemistry Enhanced Services:
- Thermodynamic Solubility Testing for Small Molecules
- Impurity Identification with Synthesis, as needed
- Metabolite Synthesis
- Synthesis of Reference Compounds and Scaffolds
- Scaling Key Intermediates from Milligrams to Kilograms
- Chemoenzymatic Approaches and Resolution Techniques for Chiral Molecules
Analytical Chemistry:
Our commitment to excellence extends beyond the lab. We leverage state-of-the-art analytical technologies like NMR, HPLC, Prep HPLC, LC-MS, and GC-MS, UV-Vis, FTIR, Polarimeter ensuring rigorous quality control and characterization of every crafted molecule.
For further information, please refer to this synthesis presentation.
Our recent publications
A Concise Formal Total Synthesis of (±)-Laurokamurene B and (±)-β-Cuparenone
Join the Chorus of Innovation:
When you choose Immunocure, you choose more than just a small molecule synthesis provider. You choose a collaborator, a co-composer in the symphony of drug discovery. Together, we can orchestrate the birth of molecules with the potential to heal, to restore, and to rewrite the future of medicine.
